Thermo Fisher Scientific GFAP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000
• Publications: 참고 문헌 보기

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000
• Publications: 참고 문헌 보기

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in mouse and rat.
• Specificity of this antibody: GFAP.

Target Information

GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family.
GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, satellite cells of peripheral ganglia, and non-myelinating Schwann cells of peripheral nerves.
Neural stem cells strongly express GFAP. Antibodies to GFAP are useful as markers of astrocytic cells and are expressed in many types of brain tumors derived from astrocytic cells.
GFAP is also found in lens epithelium, Kupffer cells of the liver, some salivary tumor cells, and erythrocytes.
It is used as a marker to distinguish astrocytes from other glial cells during development.
Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the CNS.
Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.