Thermo Fisher Scientific PTPRB Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
HPLPSYLEYRH NASIRVYQTN YFASKCAENP NSNSKSFNIK LGAEMESLGG KCDPTQQKFC DGPLKPHTAY RISIRAFTQL FDEDLKEFTK PLYSD

Highest antigen sequence identity to the following orthologs:

• Mouse: 95%
• Rat: 90%

Target Information

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains an extracellular domain, a single transmembrane segment, and one intracytoplasmic catalytic domain, classifying it as a receptor-type PTP.
The extracellular region consists of multiple fibronectin type III repeats, which interact with neuronal receptors and cell adhesion molecules such as contactin and tenascin C.
This protein also interacts with sodium channels, potentially regulating them through tyrosine phosphorylation.
These interactions suggest roles in cell adhesion, neurite growth, and neuronal differentiation.
Alternate transcript variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.