Thermo Fisher Scientific Fodrin/Alpha Spectrin II (SPTAN1)/NEAS Monoclonal Antibody (SPTAN1/3507)
인간 SPTAN1 단백질을 인식하는 마우스 모노클로날 항체로, 세포질 내 스펙트린 구조 연구에 적합합니다. IHC, Peptide Array, Immunoelectrophoresis 등 다양한 분석에 사용 가능하며, 4°C에서 안정적으로 보관됩니다.
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Thermo Fisher Scientific Fodrin/Alpha Spectrin II (SPTAN1)/NEAS Monoclonal Antibody (SPTAN1/3507)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPTAN1/3507 |
| Immunogen | Recombinant fragment of human SPTAN1 protein (around aa 2351–2475) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human colon or kidney tissues (IHC)
- Cellular Localization: Cytoplasm
- Specificity Comments: Spectrin is an actin-binding protein forming a major component of the cytoskeletal structure of the erythrocyte membrane, essential for determining membrane shape and deformability. Spectrins act as membrane organizers and stabilizers, composed of nonhomologous II, a neuronal cytoskeleton protein.
Target Information
SPTAN1 (spectrin alpha chain, non-erythrocytic 1) belongs to the spectrin family of filamentous cytoskeletal proteins. These proteins serve as scaffold structures that stabilize the plasma membrane and organize intracellular organelles. Spectrins form alpha and beta dimers that associate into tetramers in a head-to-head arrangement. SPTAN1 is involved in DNA repair and cell cycle regulation. Mutations in SPTAN1 cause early infantile epileptic encephalopathy-5. Alternate splicing leads to multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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