Thermo Fisher Scientific SLC22A2 Monoclonal Antibody (CL0631)
인간 SLC22A2 단백질을 인식하는 mouse monoclonal antibody (Clone CL0631). IHC(P)에서 1:500–1:1,000 희석으로 사용 가능. Protein A 정제, PBS/glycerol buffer에 보관. OCT2 단백질 연구에 적합하며 kidney 조직 발현 분석에 활용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0631 |
| Immunogen | Recombinant protein corresponding to Human SLC22A2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2637231 |
Product Specific Information
Immunogen sequence:
ESPRWLISQN KNAEAMRIIK HIAKKNGKSL PASLQRLRLE EETGKKLNPS FLDLVRTPQI RAntigen sequence identity:
Mouse - 84%, Rat - 77%Epitope:
Binds to an epitope located within the peptide sequence KNAEAMRIIKHIAKK as determined by overlapping synthetic peptides.
Target Information
Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from various tissues, functioning in the elimination of endogenous amines, cationic drugs, and xenobiotics.
OCTs have a 12-transmembrane-domain structure with a large extracellular hydrophilic loop.
- OCT1: Primarily expressed in the liver
- OCT2 (SLC22A2): Expressed in the kidney; mediates pH-sensitive tubular uptake of organic compounds
- OCT3: Expressed in placenta, skeletal muscle, prostate, aorta, and liver
OCT2, also known as SLC22A2, localizes to the basolateral and luminal membranes of kidney distal and proximal tubules. An additional splice variant, OCT2-A, also exists.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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