Thermo Fisher Scientific RIT1 Polyclonal Antibody
RIT1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(Paraffin) 분석에 적합합니다. Human 반응성, 항원 친화 정제, 액상 형태이며 0.75 mg/mL 농도. 신경 특이적 Ras 관련 GTPase 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 1–178 of Human RIT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548393 |
Product Specific Information
- Recommended positive control: A431
- Predicted reactivity: Mouse (97%), Zebrafish (87%), Xenopus laevis (87%), Pig (97%), Chicken (96%), Sheep (99%), Rhesus Monkey (100%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Rit and its neuron-specific homologue, Rin, define a subfamily of Ras-related GTPases. Rit and Rin are membrane-associated despite lacking a CAAX box or similar C-terminal lipidation motif. They display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is fully conserved between murine and human proteins. Rit and Rin interact with Ras-binding proteins such as RalGDS, Rlf, and AF-6, but not with Raf kinases, RIN1, or the p110 subunit of PI3 kinase. These proteins may regulate signaling pathways distinct from those controlled by Ras.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-30919_RIT1_Q92963-1_Rabbit.svg, PA5-30919_RIT1_Q92963-1_Rabbit_PDP.jpeg)
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