Thermo Fisher Scientific RIT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000
• Publications: View publication

Product Specifications

Product Specific Information

• Recommended positive control: A431
• Predicted reactivity: Mouse (97%), Zebrafish (87%), Xenopus laevis (87%), Pig (97%), Chicken (96%), Sheep (99%), Rhesus Monkey (100%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Rit and its neuron-specific homologue, Rin, define a subfamily of Ras-related GTPases. Rit and Rin are membrane-associated despite lacking a CAAX box or similar C-terminal lipidation motif. They display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is fully conserved between murine and human proteins. Rit and Rin interact with Ras-binding proteins such as RalGDS, Rlf, and AF-6, but not with Raf kinases, RIN1, or the p110 subunit of PI3 kinase. These proteins may regulate signaling pathways distinct from those controlled by Ras.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-30919_RIT1_Q92963-1_Rabbit.svg, PA5-30919_RIT1_Q92963-1_Rabbit_PDP.jpeg)