Thermo Fisher Scientific SETD7 Polyclonal Antibody
SETD7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human에 반응하며 Mouse, Rat, Rhesus Monkey에서도 예측 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 용액 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–203 of Human SETD7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548394 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HCT116
- Predicted reactivity: Mouse (96%), Rat (97%), Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3.
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation.
Plays a central role in the transcriptional activation of genes such as collagenase or insulin.
Recruited by IPF1/PDX-1 to the insulin promoter, leading to transcriptional activation.
Also methylates non-histone proteins such as p53/TP53, TAF10, and possibly TAF7.
Monomethylates Lys-189 of TAF10, increasing its affinity for RNA polymerase II.
Monomethylates Lys-372 of p53/TP53, stabilizing and enhancing p53/TP53-mediated transcriptional activation.
[UniProt]
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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