Thermo Fisher Scientific Phospho-PKR (Thr446) Recombinant Rabbit Monoclonal Antibody (ARC0293)
Recombinant rabbit monoclonal antibody recognizing phospho-PKR (Thr446). Validated for WB and ELISA. High specificity for human PKR/EIF2AK2. Supplied as liquid, affinity-purified, and stabilized in PBS with glycerol. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0293 |
| Immunogen | A synthetic phosphorylated peptide around T446 of human PKR/EIF2AK2 (P19525) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898152 |
Product Specific Information
- Positive samples: HeLa, Jurkat
- Immunogen sequence: KRTRS
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to environmental stresses. It plays a crucial role in antiviral defense through activation by double-stranded RNA produced during viral infection. PKR mediates IFN-induced innate antiviral responses, virus-induced apoptosis, and regulates cell growth and differentiation. It can induce apoptosis via Fas up-regulation and FADD/Caspase-8 signaling. PKR also modulates multiple pathways including NF-κB activation, p53, p38, and PDGF signaling. It has been implicated in tumor suppression, malignancy, and neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ALS. Viruses often inhibit PKR to evade host defenses, such as through influenza virus NS1 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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