Thermo Fisher Scientific Measles Virus Fusion Protein Polyclonal Antibody
홍역 바이러스 융합 단백질에 특이적인 토끼 폴리클로날 항체로, IHC, ICC/IF, ELISA 등 다양한 면역분석에 사용 가능. 고순도 Protein A 정제, 액상 형태로 안정적이며 연구용으로 적합. -20°C에서 보관.
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Thermo Fisher Scientific Measles Virus Fusion Protein Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50–200 |
| Immunocytochemistry (ICC/IF) | 1:50–200 |
| ELISA | 1:500–1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from Measles virus fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Class I viral fusion protein with at least three conformational states: pre-fusion native, pre-hairpin intermediate, and post-fusion hairpin. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions form a trimer-of-hairpins structure, bringing the fusion peptide near the C-terminal ectodomain region. This structure facilitates membrane apposition and subsequent fusion of viral and cellular membranes. The process is pH-independent and occurs at the outer cell membrane. The trimer of F1-F2 (F protein) interacts with H at the virion surface, and upon HN receptor binding, the hydrophobic fusion peptide engages the cellular membrane, inducing fusion. Later in infection, F proteins on infected cell membranes can mediate syncytia formation, leading to tissue necrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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