Thermo Fisher Scientific RBP3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
GPTHLFQPSL VLDMAKVLLD NYCFPENLLG MQEAIQQAIK SHEILSISDP QTLASVLTAG VQSSLNDPRL VISYEPSTPE PPPQVPALTS LSEEELLAWL QRGLRHEVLE GNVGYLRVDS VPGQEVLSMM GEFLVAHVWG NLMGTSALVL DLRHCTGGQV SGIPYIISYL HPGNTILHVD TIYNRPSNTT TEIWTLPQVL GERYGADKDV VVLTSSQTRG VAEDIAHILK QMRRAIVVGE RTGGGALDLR KLRIGESDFF FTVPVSRSLG PLGGGSQTWE GSGVLPCVGT PAEQALEKAL AIL

Positive Samples: Mouse lung, Mouse eye, Rat eye
Cellular Location: Extracellular matrix, extracellular space, interphotoreceptor matrix

Target Information

Interphotoreceptor retinol-binding protein (IRBP) is a large glycoprotein that binds retinoids and is primarily found in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and photoreceptor cells. It facilitates retinoid transport between these structures, playing a critical role in the visual process.
The human IRBP gene (~9.5 kbp) comprises four exons and three introns (1.6–1.9 kbp each). The gene produces a 4.3-kb mRNA that translates into a glycosylated 135 kDa protein. The amino acid sequence includes four homology domains (33–38% identity), likely resulting from gene duplication events. The first large exon encodes most of these domains (3,180 bp), while the last three exons encode the remainder (191, 143, and ~740 bp).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.