Thermo Fisher Scientific RBP3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 18-320 of human RBP3 (NP_0028911) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RBP3,uniProtId:P10745-1,ncbiNodeId:9606,antigenRange:18-320,antigenLength:1247,antigenImageFileName:PA5-92951_RBP3_P10745-1_Rabbit.svg,antigenImageFileNamePDP:PA5-92951_RBP3_P10745-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.97 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806558

Product Specific Information

Immunogen sequence: GPTHLFQPSL VLDMAKVLLD NYCFPENLLG MQEAIQQAIK SHEILSISDP QTLASVLTAG VQSSLNDPRL VISYEPSTPE PPPQVPALTS LSEEELLAWL QRGLRHEVLE GNVGYLRVDS VPGQEVLSMM GEFLVAHVWG NLMGTSALVL DLRHCTGGQV SGIPYIISYL HPGNTILHVD TIYNRPSNTT TEIWTLPQVL GERYGADKDV VVLTSSQTRG VAEDIAHILK QMRRAIVVGE RTGGGALDLR KLRIGESDFF FTVPVSRSLG PLGGGSQTWE GSGVLPCVGT PAEQALEKAL AIL; Positive Samples: Mouse lung, Mouse eye, Rat eye; Cellular Location: extracellular matrix, extracellular space, interphotoreceptor matrix

Target Information

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.