Thermo Fisher Scientific PTPRN Polyclonal Antibody
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
PA592949 | - | Thermo Fisher Scientific PA592949 PTPRN Polyclonal Antibody 100 ul pk | 재고문의 | pk | 621,000원 | - | 683,100원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
1:500-1:2,000
Immunocytochemistry (ICC/IF)
1:100
ELISA (ELISA)
1 µg/mL
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 600-889 of human PTPRN (NP_0011866931) if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
PTPRN,
uniProtId:
Q16849-1,
ncbiNodeId:
9606,
antigenRange:
600-889,
antigenLength:
979,
antigenImageFileName:
PA5-92949_PTPRN_Q16849-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-92949_PTPRN_Q16849-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.77 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806556
Product Specific Information
Immunogen sequence: STGHMILAYM EDHLRNRDRL AKEWQALCAY QAEPNTCATA QGEGNIKKNR HPDFLPYDHA RIKLKVESSP SRSDYINASP IIEHDPRMPA YIATQGPLSH TIADFWQMVW ESGCTVIVML TPLVEDGVKQ CDRYWPDEGA SLYHVYEVNL VSEHIWCEDF LVRSFYLKNV QTQETRTLTQ FHFLSWPAEG TPASTRPLLD FRRKVNKCYR GRSCPIIVHC SDGAGRTGTY ILIDMVLNRM AKGVKEIDIA ATLEHVRDQR PGLVRSKDQF EFALTAVAEE VNAILKALPQ; Positive Samples: 293T, NIH/3T3, Raji, Mouse brain, Rat brian; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Perikaryon, Single-pass type I membrane protein, axon, secretory vesicle membrane, synapse
Target Information
IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells. The IA-2 protein is 979 amino acids in length and consists of a luminal domain, transmembrane domain, and cytoplasmic domain. Although a member of the PTP family, IA-2 lacks phosphatase activity with known substrates due to amino acid substitutions at critical sites in its PTP domain. Two paralog RPTPs, IA-2 and IA-2beta were identified as major autoantigens in type-1 diabetes mellitus. On granule exocytosis, the IA-2 cytoplasmic domain is cleaved and the resulting cytosolic fragment moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis. IA-2 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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