Thermo Fisher Scientific NUP107 Polyclonal Antibody
NUP107 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 생쥐에서 반응하며, 농도 0.5 mg/mL 액상 형태입니다. 합성 펩타이드 면역원 사용, 연구용으로만 제공됩니다.
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- PA519334
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- pk
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Thermo Fisher Scientific NUP107 Polyclonal Antibody
Applications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (PLPAEDDNAIREH) corresponding to the internal amino acids of NUP107 (aa 735–747) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983657 |
Product Specific Information
- Predicted to react with bovine, canine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm.
The mammalian nucleoporin (NUP107) is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and the mammalian homolog of yeast sec13p.
While most of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells, associated with proteins such as Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107-160 complex results in defective spindle assembly, indicating multiple functions.
NUP107 has been identified as an HIV dependency factor (HDF), suggesting its potential as a drug target for HIV treatment.
Multiple isoforms of NUP107 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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