Thermo Fisher Scientific ABCC5 Monoclonal Antibody (OTI5A8), TrueMAB

Applications

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The ABCC5 gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. These proteins mediate the transport of various molecules across cellular membranes. ABCC5 belongs to the MRP subfamily, associated with multidrug resistance. It facilitates the export of cyclic nucleotides, contributing to their degradation and elimination. This protein provides resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. It may be involved in thiopurine resistance in acute lymphoblastic leukemia and antiretroviral resistance in HIV-infected patients. Alternative splicing of this gene has been observed, though the full sequence and initiation site remain unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.