ELK Biotechnology Cleaved-Caspase-6 p11 (A194) rabbit pAb
Cleaved-Caspase-6 p11 (A194) rabbit polyclonal antibody. WB 및 ELISA에 적합하며, 사람, 생쥐, 랫트에 반응. 세포자멸사 관련 단백질 검출에 유용. 고순도 IgG, -20°C에서 1년 보관 가능.
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Cleaved-Caspase-6 p11 (A194) rabbit pAb
제품 개요
Cleaved-Caspase-6 p11 (A194)는 세포자멸사(apoptosis) 경로에서 중요한 역할을 하는 cysteine-aspartic protease 계열 단백질을 인식하는 토끼 폴리클로날 항체입니다. Caspase 계열의 연속적 활성화는 세포사멸의 실행 단계에서 중심적인 역할을 하며, 본 항체는 Caspase-6의 절단 형태를 특이적으로 검출합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Caspase-6 p11 (A194) rabbit pAb |
| Alternative Names | caspase 6, apoptosis-related cysteine peptidase |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:10000–20000 |
| Immunogen | Synthesized peptide derived from Cleaved-Caspase-6 p11 (A194), AA range: 150–230 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 33 kDa |
| GeneID (Human) | 839 |
| Human Swiss-Prot No. | P55212 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, which dimerize to form the active enzyme. This protein is processed by caspases 7, 8, and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [RefSeq, Oct 2015]
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