ELK Biotechnology Atm (phospho Ser1981) rabbit pAb
ATM 단백질의 Ser1981 인산화 상태를 검출하는 고품질 토끼 다클론 항체. WB, IHC, IF, ELISA에 적합하며 인간, 생쥐, 랫트 시료 반응. 세포 주기 체크포인트 및 DNA 손상 반응 연구에 유용.
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제품명
Atm (phospho Ser1981) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
ATM 단백질의 Ser1981 인산화 부위를 특이적으로 인식하는 토끼 다클론 항체입니다. 세포 주기 조절 및 DNA 손상 반응 관련 연구에 적합합니다.
제품 상세 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 – 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Atm (phospho Ser1981) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 350 kD |
| GeneID (Human) | 472 |
| Human Swiss-Prot No | Q13315 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus; Cytoplasmic vesicle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. |
Background
The protein encoded by this gene belongs to the PI3/PI4-kinase family. It acts as a key cell cycle checkpoint kinase that phosphorylates and regulates various downstream proteins, including tumor suppressors p53 and BRCA1, checkpoint kinases CHK2, RAD17, RAD9, and DNA repair protein NBS1. ATM and ATR are considered master controllers of cell cycle checkpoint signaling pathways essential for DNA damage response and genome stability. Mutations in this gene cause ataxia telangiectasia, an autosomal recessive disorder. (RefSeq, Aug 2010)
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