ELK Biotechnology Factor XIII B rabbit pAb
Factor XIII B rabbit polyclonal antibody for WB, IHC, IF, ELISA applications. Targets human F13B involved in coagulation. High specificity with observed band at 65kD. Suitable for human, rat, and mouse samples. Long-term storage at -20°C.
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Factor XIII B rabbit pAb
Supplier: ELK Biotechnology
제품 개요
Factor XIII B rabbit polyclonal antibody는 혈액 응고 인자 XIII의 B 서브유닛을 인식하는 항체로, Western Blot, IHC, IF, ELISA 등의 다양한 응용에 적합합니다. 인체, 랫, 마우스 시료에서 반응성을 보입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Factor XIII B rabbit pAb |
| Alternative Names | F13B; Coagulation factor XIII B chain; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000; IHC-p: 1:100–1:300; ELISA: 1/10000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human F13B (AA range: 500–550) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kD |
| GeneID (Human) | 2165 |
| Human Swiss-Prot No | P05160 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes the coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of two A subunits identical to those of plasma origin. Upon activation by thrombin cleavage and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the fibrin clot. Factor XIII deficiency is associated with coagulation disorders.
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