ELK Biotechnology Axl rabbit pAb
Axl rabbit polyclonal antibody for WB and ELISA applications. Recognizes AXL receptor tyrosine kinase involved in cell growth and signaling. Suitable for human, mouse, and rat samples. Long-term storage at -20°C.
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Axl rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | AXL; UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from Axl (AA range: 630-710) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kD |
| GeneID (Human) | 558 |
| Human Swiss-Prot No | P30530 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Storage | -20°C / 1 year |
| Host | Rabbit |
배경 (Background)
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation, and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
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