ELK Biotechnology ADAMTS-2 rabbit pAb
ADAMTS-2 단백질을 인식하는 토끼 다클론 항체로, Western Blot 및 ELISA에 적합합니다. 인간, 쥐, 생쥐 시료에 반응하며, 세포외 기질 단백질 연구에 유용합니다. -20°C에서 1년간 보관 가능합니다.
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ADAMTS-2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ADAMTS-2 rabbit pAb |
| Alternative Names | ADAMTS2; PCINP; PCPNI; A disintegrin and metalloproteinase with thrombospondin motifs 2; ADAM-TS 2; ADAM-TS2; ADAMTS-2; Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from ADAMTS-2 (AA range: 1140–1220) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kD |
| Gene ID (Human) | 9509 |
| Human Swiss-Prot No. | O95450 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase, which excises the N-propeptide of the fibrillar procollagens types I–III and type V.
Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder.
Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
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