ELK Biotechnology p38 rabbit pAb
MAPK14 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 인간 p38의 C-말단 유래 펩타이드를 면역원으로 사용하였으며, 세포 내 스트레스 반응 및 신호전달 연구에 활용 가능합니다. -20°C에서 1년 보관.
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ELK Biotechnology p38 rabbit pAb
제품 설명
p38 rabbit pAb는 MAPK14 단백질을 인식하는 토끼 폴리클로날 항체로, 다양한 세포 신호전달 및 스트레스 반응 연구에 사용됩니다. 이 단백질은 MAP kinase 계열에 속하며, 세포 증식, 분화, 전사 조절 및 발달 과정에 관여합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | p38 rabbit pAb |
| Alternative Names | MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; SAPK2a |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the C-terminal region of human p38 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kD |
| GeneID (Human) | 1432 |
| Human Swiss-Prot No | Q16539 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human; Mouse; Rat; Chicken (tested by our customer) |
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is activated by environmental stresses and proinflammatory cytokines. Activation requires phosphorylation by MAP kinase kinases (MKKs) or autophosphorylation triggered by interaction with MAP3K7IP1/TAB1. Substrates include transcription regulators ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, suggesting roles in stress-related transcription, cell cycle regulation, and genotoxic stress response. Four alternatively spliced transcript variants of this gene have been identified.
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