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ELK Biotechnology ACAP1 (phospho Ser554) rabbit pAb

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ACAP1 단백질의 Ser554 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능하며 다양한 종(Human, Rat, Mouse)에 반응. 재활용 엔도솜 막 단백질 연구에 적합. -20°C에서 1년 보관 가능.

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ELK Biotechnology ES8095-100UL ACAP1 (phospho Ser554) rabbit pAb, 100UL pk판매 단위 pk ·

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402,000원VAT 포함 442,200원

ELK Biotechnology ES8095-50UL ACAP1 (phospho Ser554) rabbit pAb, 50UL pk판매 단위 pk ·

재고 확인 필요재고 확인 필요

301,000원VAT 포함 331,100원

재고문의·견적요청 옵션은 실시간 상담으로 납기를 확인해 드립니다 · 연구비 카드 결제 가능

ACAP1 (phospho Ser554) rabbit pAb

항목	내용
Alternative Names	ACAP1; CENTB1; KIAA0050; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1
Applications	WB; IHC; IF; ELISA
Recommended Dilutions	IHC: 1/100–1/300 ELISA: 1/40000 Other applications not yet tested
Immunogen	Synthesized peptide derived from human Centaurin-beta1 around the phosphorylation site of Ser554 (AA range: 520–569)
Host	Rabbit
Storage	-20°C / 1 year
Clonality	Polyclonal
Isotype	IgG
Concentration	1 mg/ml
Gene ID (Human)	9744
Human Swiss-Prot No.	Q15027
Cellular Localization	Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side
Species Reactivity	Human; Rat; Mouse

Domain: PH domain binds phospholipids including phosphatidic acid, PI3P, PI(3,5)P₂, and PI(3,4,5)P₃.
Enzyme Regulation: GAP activity stimulated by PI(4,5)P₂ and phosphatidic acid.
Function: Acts as a GTPase-activating protein (GAP) for ARF6, essential for clathrin-dependent export of proteins from recycling endosomes to the trans-Golgi network and cell surface.
Miscellaneous:
- Overexpression causes accumulation of ITGB1 in recycling endosomes and inhibits stimulation-dependent cell migration.
- Reduced ACAP1 or AKT1/2 levels inhibit cell migration.
- Co-expression with PIP5K1C induces tubular endosomal membrane structures.
PTM: Phosphorylation at Ser-554 by PKB is required for ITGB1 interaction and export from recycling endosomes to the cell surface.
Similarity: Contains 1 Arf-GAP domain, 1 BAR domain, 1 PH domain, and 3 ANK repeats.
Subunit: Interacts with GTP-bound ARF6, SLC2A4/GLUT4, CLTC, and GULP1. Forms a complex with GDP-bound ARF6 and GULP1.
Tissue Specificity: Highest expression in lung and spleen; low in heart, kidney, liver, and pancreas.

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