ELK Biotechnology MDC1 (phospho Ser513) rabbit pAb
MDC1 단백질의 Ser513 인산화 부위를 인식하는 토끼 폴리클로날 항체. IHC, IF, ELISA에 사용 가능하며 인간, 생쥐, 랫트 시료에 반응. DNA 손상 반응 연구에 적합한 핵 내 단백질 타깃 항체. -20°C에서 1년 보관 가능.
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제품명
MDC1 (phospho Ser513) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MDC1; KIAA0170; NFBD1; Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MDC1 around the phosphorylation site of Ser513 (AA range: 479–528) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 9656 |
| Human Swiss-Prot No. | Q14676 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Nucleus; Chromosome; Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, requiring Ser-139 phosphorylation of H2AX. Colocalizes with APTX at sites of DNA double-strand breaks. |
Background
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs, and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
[provided by RefSeq, Jul 2008]
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