원본
ELK Biotechnology Fish rabbit pAb
상품 한눈에 보기
인간 및 마우스 시료에 반응하는 Fish rabbit 다클론 항체로, IHC, IF, WB, ELISA 등 다양한 응용에 적합합니다. 세포질 및 podosome에 주로 위치하며, 암세포 침습성과 관련된 단백질 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다회원가입 없이 바로 구매하세요
가입하지 않아도 비회원가로 구매하실 수 있습니다.
카탈로그 번호 · 상품 설명출고판매가담기
ELK Biotechnology ES8080-100UL Fish rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES8080-50UL Fish rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Fish rabbit pAb
제품명
Fish rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SH3PXD2A; FISH; KIAA0418; SH3MD1; TKS5; SH3 and PX domain-containing protein 2A; Adapter protein TKS5; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains |
| Applications | IHC; IF; WB; ELISA |
| Recommended Dilutions | IHC-p 1:100–500; IF/ICC 1:100–500; WB 1:500–2000; ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Fish |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 9644 |
| Human Swiss-Prot No. | Q5TCZ1 |
| Cellular Localization | Cytoplasm; Cell projection, podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. |
| Species Reactivity | Human; Mouse |
Background
- Domain: The fifth SH3 domain mediates binding with ADAM12, ADAM15, and ADAM19. The PX domain is required for podosome localization and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2).
- Function: Required for podosome formation, extracellular matrix degradation, and invasiveness of certain cancer cells. Binds PtdIns(3)P and PtdIns(3,4)P2. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
- PTM: Tyrosine phosphorylated by SRC; phosphorylation regulates localization. Serine phosphorylation upon DNA damage likely mediated by ATM or ATR.
- Similarity: Belongs to the SH3PXD2 family; contains one PX domain and five SH3 domains.
- Subunit Interaction: Interacts with ADAM12, ADAM15, and ADAM19.
- Tissue Specificity: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.
ELK Biotechnology 상품 둘러보기
전체보기
ELK BiotechnologyELK Biotechnology Cyclin E1 (phospho Thr77) rabbit pAb301,000원VAT별도
ELK BiotechnologyELK Biotechnology Neuron Navigator 1 rabbit pAb301,000원VAT별도
ELK BiotechnologyELK Biotechnology DDR1 rabbit pAb301,000원VAT별도
ELK BiotechnologyELK Biotechnology Olfactory receptor 3A2/3A3 rabbit pAb301,000원VAT별도
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.