ELK Biotechnology AKAP 250 rabbit pAb
AKAP 250 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 인간, 랫드, 마우스 반응성. 세포 골격 및 세포막 위치 단백질 검출에 적합. 신호전달 연구 및 세포 성장 관련 단백질 분석에 유용.
- 판매단위
- pk
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제품명
AKAP 250 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | AKAP12; AKAP250; A-kinase anchor protein 12; AKAP-12; A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AKAP12 (AA range: 301-350) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 9590 |
| Human Swiss-Prot No | Q02952 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, cell cortex, cytoskeleton, membrane (lipid-anchor). May be part of the cortical cytoskeleton. |
Background
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that share the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell.
This gene encodes a member of the AKAP family, expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, serving as a scaffold protein in signal transduction.
AKAP12 and RII PKA colocalize at the cell periphery and are related to cell growth. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing results in two transcript variants encoding different isoforms.
[provided by RefSeq, Jul 2008]
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