ELK Biotechnology JIP-1 (phospho Thr103) rabbit pAb
JIP-1 (phospho Thr103) rabbit pAb는 인산화된 Thr103 부위를 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능합니다. 인간, 마우스, 랫트 시료에 반응하며 세포 내 다양한 위치에서 JIP-1 단백질을 검출할 수 있습니다. -20°C에서 1년 보관 가능합니다.
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제품명
JIP-1 (phospho Thr103) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAPK8IP1; IB1; JIP1; PRKM8IP; C-Jun-amino-terminal kinase-interacting protein 1; JIP-1; JNK-interacting protein 1; Islet-brain 1; IB-1; JNK MAP kinase scaffold protein 1; Mitogen-activated protein kinase 8-interacting protein 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human JIP1 around the phosphorylation site of Thr103 (AA range: 69–118) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 113 kD |
| Gene ID (Human) | 9479 |
| Human Swiss-Prot No. | Q9UQF2 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; Cytoplasm, perinuclear region; Nucleus; Endoplasmic reticulum membrane; Mitochondrion membrane; Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). |
Background
This gene encodes a regulator of pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8-mediated activation of transcription factors and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1)-induced apoptosis in pancreatic beta cells. It also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. Mutations in this gene have been found in a type 2 diabetes family, suggesting it is a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
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