ELK Biotechnology ARK-2 (phospho Tyr12) rabbit pAb
Aurora kinase B 인산화형(Tyr12)을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합. 인간, 마우스, 랫트 반응성. 세포 분열 중 염색체와 방추체 위치 연구에 유용하며 -20°C에서 1년 보관 가능.
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제품명
ARK-2 (phospho Tyr12) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human AurB around the phosphorylation site of Tyr12 (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 39 kD |
| GeneID (Human) | 9212 |
| Human Swiss-Prot No | Q96GD4 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치(Cellular Localization)
Nucleus, Chromosome, Centromere, Kinetochore, Cytoplasm (cytoskeleton, spindle), Midbody.
Localizes on chromosome arms and inner centromeres from prophase through metaphase, then transfers to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:20929775).
Colocalized with gamma tubulin in the midbody (PubMed:17726514).
Proper localization of the active, Thr-232-phosphorylated form during metaphase may depend on interaction with SPDYC (PubMed:20605920).
Colocalized with SIRT2 during cytokinesis with the midbody (PubMed:17726514).
Localization (and CPC targeting) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12.
Background
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases.
Other members of this subfamily are located on chromosomes 19 and 20.
Aurora kinases regulate chromosome alignment and segregation during mitosis and meiosis through association with microtubules.
A pseudogene of this gene is located on chromosome 8.
Alternatively spliced transcript variants have been found for this gene.
[Provided by RefSeq, Sep 2015]
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