ELK Biotechnology ACTR-IIA rabbit pAb
ACTR-IIA 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포막 단일 통과형 단백질을 타깃으로 합니다. -20°C에서 1년 보관 가능합니다.
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제품명
ACTR-IIA rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ACVR2A; ACVR2; Activin receptor type-2A; Activin receptor type IIA; ACTR-IIA; ACTRIIA |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ACTR-IIA. AA range: 10-59 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| GeneID (Human) | 92 |
| Human Swiss-Prot No | P27037 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes.
The encoded protein is a transmembrane serine-threonine kinase receptor that mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner.
The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain, and a cytoplasmic serine-threonine kinase domain.
This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality.
Alternative splicing results in multiple transcript variants of this gene.
[provided by RefSeq, Jun 2013]
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