ELK Biotechnology LATS1/2 (phospho Thr1079/1041) rabbit pAb
LATS1/2 인산화 Thr1079/1041 부위를 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 세포 주기 관련 단백질 복합체 연구 및 종양 억제 기전 분석에 적합. 인간과 생쥐 반응성. -20°C에서 1년 보관.
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제품명
LATS1/2 (phospho Thr1079/1041) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | LATS1; WARTS; Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts; LATS2; KPM; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LATS1/2 around the phosphorylation site of Thr1079/1041 (AA range: 1041–1090) |
| Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 9113 / 26524 |
| Human Swiss-Prot No | O95835 / Q9NRM7 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Cytoplasm, cytoskeleton, spindle, midbody, spindle pole body.
Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
배경 정보
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor, supported by knockout mouse studies showing development of soft-tissue sarcomas, ovarian stromal cell tumors, and high sensitivity to carcinogenic treatment.
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