ELK Biotechnology Claudin-1 rabbit pAb
Claudin-1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 세포 접합부 연구에 활용되며, 인간, 마우스, 랫트 시료에 반응합니다. 고순도 IgG 형태로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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Claudin-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Claudin-1 rabbit pAb |
| Alternative Names | CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Claudin 1 (AA range: 162-211) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 30 kD |
| Gene ID (Human) | 9076 |
| Human Swiss-Prot No. | O95832 |
| Cellular Localization | Cell junction, tight junction, cell membrane; multi-pass membrane protein; basolateral cell membrane. Associates with CD81, and the CLDN1-CD81 complex localizes to the basolateral cell membrane. |
| Species Reactivity | Human; Mouse; Rat |
Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.
The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
[Provided by RefSeq, Jul 2008]
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