ELK Biotechnology BinCARD rabbit pAb

제품명

BinCARD rabbit pAb

대체 명칭

C9orf89; Bcl10-interacting CARD protein; BinCARD

적용 분야

IHC, IF, ELISA

권장 희석 배율

• Immunohistochemistry: 1/100 - 1/300
• ELISA: 1/40000
• 기타 응용은 아직 테스트되지 않음

면역원

Synthesized peptide derived from human C9orf89 (AA range: 21–70)

저장 조건

• 종: Rabbit
• 보관: -20°C, 1년

항체 특성

세포 내 위치

• Isoform 1: Nucleus. Coexpression with BCL10 induces translocation from nucleus to cytosol.
• Isoform 2: Endoplasmic reticulum membrane; single-pass membrane protein. Also found in mitochondrion membrane; single-pass membrane protein.

배경 정보

• Function: Plays a role in inhibiting BCL10-induced activation of NF-κB. May inhibit phosphorylation of BCL10 in a CARD-dependent manner.
• PTM: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.
• Similarity: Contains one CARD domain.
• Subcellular location: Co-expression with BCL10 induces translocation from nucleus to cytosol.
• Subunit: Associates with BCL10 via CARD–CARD interaction.
• Tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart, liver (protein level), thymus, and brain.