ELK Biotechnology Cyclin D2 (phospho Thr280) rabbit pAb
Cyclin D2 단백질의 Thr280 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 적합하며, 세포주기 G1/S 전이 연구에 활용 가능. 인간, 마우스, 랫트 반응성. -20°C에서 1년 보관.
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Cyclin D2 (phospho Thr280) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Cyclin D2 (phospho Thr280) rabbit pAb |
| Alternative Names | CCND2; G1/S-specific cyclin-D2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Cyclin D2 around the phosphorylation site of Thr280 (AA range: 240–289) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kDa |
| Gene ID (Human) | 894 |
| Human Swiss-Prot No. | P30279 |
| Cellular Localization | Nucleus; Cytoplasm; Nuclear membrane. Cyclin D–CDK4 complexes accumulate at the nuclear membrane and translocate into the nucleus via interaction with KIP/CIP family members. Isoform 2: Cytoplasm |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, characterized by periodic protein abundance through the cell cycle. Cyclins regulate CDK kinases, and distinct expression/degradation patterns ensure proper mitotic timing. Cyclin D2 forms a complex with CDK4 or CDK6, acting as a regulatory subunit essential for G1/S transition. It interacts with and phosphorylates the tumor suppressor protein Rb. Knockout studies in mice indicate essential roles in ovarian granulosa and germ cell proliferation. High expression levels are observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly.
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