ELK Biotechnology Cdc16 rabbit pAb
Cdc16 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA 등에 사용 가능. 인간 APC6 유래 펩타이드로 면역화됨. 세포주기 조절 및 APC 복합체 연구에 적합. Human, Mouse, Rat 반응성.
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Cdc16 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cdc16 rabbit pAb |
| Alternative Names | CDC16; ANAPC6; Cell division cycle protein 16 homolog; Anaphase-promoting complex subunit 6; APC6; CDC16 homolog; CDC16Hs; Cyclosome subunit 6 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human APC6 (AA range: 181-230) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 72 kDa |
| GeneID (Human) | 8881 |
| Human Swiss-Prot No | Q13042 |
| Cellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, and spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degradation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain, which is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants encoding distinct proteins have been identified. (RefSeq, Jan 2016)
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