ELK Biotechnology Cdc16 (phospho Ser560) rabbit pAb
Cdc16 (phospho Ser560) rabbit polyclonal antibody는 인간 CDC16/APC6의 Ser560 인산화 부위를 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며 고순도 IgG 형식으로 제공됩니다. 세포주기 조절 및 APC 복합체 연구에 적합합니다.
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Cdc16 (phospho Ser560) rabbit pAb
제품 개요
Cdc16 (phospho Ser560) rabbit polyclonal antibody는 인간 CDC16/APC6 단백질의 Ser560 인산화 부위를 특이적으로 인식하도록 제작된 항체입니다. 세포주기 조절 및 APC 복합체 관련 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cdc16 (phospho Ser560) rabbit pAb |
| Alternative Names | CDC16; ANAPC6; Cell division cycle protein 16 homolog; Anaphase-promoting complex subunit 6; APC6; CDC16 homolog; CDC16Hs; Cyclosome subunit 6 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CDC16/APC6 around the phosphorylation site of Ser560 (AA range: 526–575) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 72 kD |
| Gene ID (Human) | 8881 |
| Human Swiss-Prot No | Q13042 |
| Cellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle. |
| Species Reactivity | Human; Mouse |
Background
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degradation via the 26S proteasome. Each component of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain, which is often involved in protein-protein interactions and multiprotein complex assembly. Multiple alternatively spliced transcript variants encoding distinct proteins have been identified.
[provided by RefSeq, Jan 2016]
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