ELK Biotechnology PXR rabbit pAb
PXR 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot과 ELISA에 적합합니다. 인간, 랫드, 마우스 시료에 반응하며, 핵 내 수용체 단백질 연구에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology PXR rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PXR rabbit pAb |
| Alternative Names | NR1I2; PXR; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NR1I2. AA range: 91-140 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 8856 |
| Human Swiss-Prot No | O75469 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist; however, they have not been fully characterized.
[provided by RefSeq, Jul 2008]
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