ELK Biotechnology FADD (phospho Ser194) rabbit pAb
FADD 단백질의 Ser194 인산화 부위를 인식하는 토끼 폴리클로날 항체로, 세포 사멸 신호 전달 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 사람과 생쥐 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
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FADD (phospho Ser194) rabbit pAb
제품 개요
FADD 단백질의 Ser194 인산화 부위를 인식하는 토끼 폴리클로날 항체로, 세포 사멸 관련 신호전달 연구에 유용합니다. 다양한 응용 분야(WB, IHC, IF, ELISA)에 사용할 수 있으며, 사람 및 생쥐 시료에 반응합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | FADD (phospho Ser194) rabbit pAb |
| Alternative Names | FADD; MORT1; GIG3; Protein FADD; FAS-associated death domain protein; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human FADD around the phosphorylation site of Ser194 (AA range: 159–208) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 28 kD |
| Gene ID (Human) | 8772 |
| Human Swiss-Prot No. | Q13158 |
| Cellular Localization | Cytoplasm, cytosol, plasma membrane, death-inducing signaling complex, CD95 death-inducing signaling complex, neuron projection, cell body, membrane raft, ripoptosome |
| Species Reactivity | Human; Mouse |
Background
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8 and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
[provided by RefSeq, Jul 2008]
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