ELK Biotechnology Dab1 (phospho Tyr232) rabbit pAb
Dab1 (phospho Tyr232) rabbit polyclonal antibody for WB, IF, ELISA. Recognizes phosphorylated Dab1 around Tyr232. Suitable for human, mouse, and rat samples. High specificity and stability with storage at -20°C for up to 1 year.
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제품명
Dab1 (phospho Tyr232) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DAB1; Disabled homolog 1 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Dab1 around the phosphorylation site of Tyr232 (AA range: 199–248) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 8674 |
| Human Swiss-Prot No | O75553 |
| Cellular Localization | nucleolus, microtubule organizing center, cytosol, brush border, postsynaptic density, membrane, neuron projection, neuronal cell body, intracellular membrane-bounded organelle, apical part of cell, perinuclear region of cytoplasm |
| Species Reactivity | Human; Mouse; Rat |
Background
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full-length nature has not been determined. (Provided by RefSeq, Jul 2008)
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