ELK Biotechnology DD3 rabbit pAb
인간 AKR1C3 단백질을 인식하는 토끼 폴리클로날 항체. WB 및 ELISA에 사용 가능하며, 세포질에 주로 발현. 37kDa 밴드 검출, -20°C에서 1년 보관 가능. 인간, 생쥐, 랫트 반응성.
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제품명
DD3 rabbit pAb
제품 설명
DD3 rabbit pAb는 인간 AKR1C3 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. 이 항체는 Western blot 및 ELISA 분석에 적합하며, 세포질에서 주로 발현되는 단백질을 검출합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DD3 rabbit pAb |
| Alternative Names | AKR1C3; DDH1; HSD17B5; KIAA0119; PGFS; Aldo-keto reductase family 1 member C3; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 3-alpha-HSD type II; brain; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; Chlordec |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AKR1C3. AA range: 191-240 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 37 kD |
| Gene ID (Human) | 8644 |
| Human Swiss-Prot No. | P42330 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2, and phenanthrenequinone (PQ), and the oxidation of 9α,11β-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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