ELK Biotechnology PRAK rabbit pAb
PRAK rabbit pAb는 MAPKAPK5 단백질을 인식하는 폴리클로날 항체로, WB와 IHC에 적합합니다. 세포 스트레스 반응 연구에 활용되며, 인간 및 생쥐 시료에서 반응합니다. 세포 내 위치와 인산화에 따른 이동 연구에 유용합니다.
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제품명
PRAK rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAPKAPK5; PRAK; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAPKAPK5. AA range: 148–197 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| Gene ID (Human) | 8550 |
| Human Swiss-Prot No. | Q8IW41 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm, Nucleus. Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182 activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export. |
Background
The protein encoded by this gene is a tumor suppressor and a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. It phosphorylates heat shock protein HSP27 at physiologically relevant sites. Two alternately spliced transcript variants encoding distinct isoforms have been reported.
[Provided by RefSeq, Nov 2012]
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