ELK Biotechnology Caspase-6 (phospho Ser257) rabbit pAb
Caspase-6 (phospho Ser257)을 인식하는 토끼 폴리클로날 항체로, 인간, 마우스, 랫트에 반응합니다. WB, IHC, IF, ELISA에 사용 가능하며 세포자멸사 연구에 적합합니다. 합성 펩타이드 면역원으로 제작되어 높은 특이성과 재현성을 제공합니다.
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Caspase-6 (phospho Ser257) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Caspase-6 (phospho Ser257) rabbit pAb |
| Alternative Names | CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human Caspase 6 around the phosphorylation site of Ser257 (AA range: 223–272) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 15, 30 kDa |
| Gene ID (Human) | 839 |
| Human Swiss-Prot No | P55212 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic acid residues to produce large and small subunits, which dimerize to form the active enzyme. Caspase-6 is processed by caspases 7, 8, and 10, and functions as a downstream enzyme in the caspase activation cascade. Alternative splicing results in multiple transcript variants encoding different isoforms.
[Provided by RefSeq, Oct 2015]
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