ELK Biotechnology Caspase-8 (phospho Ser347) rabbit pAb
Caspase-8의 Ser347 인산화 부위를 인식하는 토끼 폴리클로날 항체로, 세포 사멸 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 사람 및 랫트 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Caspase-8 (phospho Ser347) rabbit pAb
Caspase-8 (phospho Ser347) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Caspase-8 (phospho Ser347) rabbit pAb |
| Alternative Names | CASP8; MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase 8 around the phosphorylation site of Ser347 (AA range: 313–362) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| Gene ID (Human) | 841 |
| Human Swiss-Prot No. | Q14790 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Rat |
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain suggests interaction with Fas-interacting protein FADD. It was detected in insoluble fractions of affected brain regions from Huntington disease patients, implicating a potential role in neurodegenerative diseases.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.