Thermo Fisher Scientific Phospho-Complement C5a Receptor 1 (Thr336) Polyclonal Antibody
인간 C5a 수용체 1의 Thr336 인산화 부위에 특이적인 폴리클로날 항체입니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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- 7TM0032C
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | Not applicable (N/A) |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human C5a1 around the phosphorylation site of Thr336. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known.
C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release, and superoxide anion production.
CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex.
Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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