
Thermo Fisher Scientific HCoV-OC43 Spike S2 Polyclonal Antibody
HCoV-OC43 Spike S2 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제 제품이며, 액상 형태로 -20°C에서 보관합니다. 연구용으로 바이러스 단백질 분석에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (aa 782–881 of coronavirus Spike S2, YP_0095552411) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.95 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914343 |
Product Specific Information
Positive test controls include: Human coronavirus (HCoV-OC43) Spike Protein (S1+S2 ECDHis Tag).
Immunogen sequence:
EPVGGLYEIQ IPSEFTIGNM VEFIQTSSPK VTIDCAAFVC GDYAACKSQL VEYGSFCDNI NAILTEVNEL LDTTQLQVAN SLMNGVTLST KLKDGVNFNV
Target Information
The S2 Spike protein mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide near the C-terminal region of the ectodomain. The formation of this structure drives apposition and subsequent fusion of viral and target cell membranes. [Uniprot]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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