Thermo Fisher Scientific ALX3 Polyclonal Antibody

Applications

• Western Blot (WB): Tested at 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%

Target Information

Aristaless-related genes are a group of paired-related homeobox genes involved in regulating vertebrate embryogenesis. The homeodomain transcription factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and lateral plate mesoderm. Expression analysis of human and mouse tissues shows predominant ALX3 expression in brain tissue.
The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression.
Alx3 (-) mice show no phenotype distinct from wild-type mice; however, Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities, including cleft nasal regions and malformation of other neural crest-derived skull structures.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.