Thermo Fisher Scientific ALX3 Polyclonal Antibody
Rat ALX3 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot에 적합. 합성 펩타이드 면역원으로 제작되었으며, PBS와 sucrose buffer에 보관. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공.
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Applications
- Western Blot (WB): Tested at 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of rat ALX3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690504 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%
Target Information
Aristaless-related genes are a group of paired-related homeobox genes involved in regulating vertebrate embryogenesis. The homeodomain transcription factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and lateral plate mesoderm. Expression analysis of human and mouse tissues shows predominant ALX3 expression in brain tissue.
The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression.
Alx3 (-) mice show no phenotype distinct from wild-type mice; however, Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities, including cleft nasal regions and malformation of other neural crest-derived skull structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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