ELK Biotechnology S12A1 rabbit pAb
S12A1 rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에 반응. WB에 사용 가능하며 1:500–2000 희석 권장. 인간 S12A1 유래 합성 펩타이드 면역원 사용. 신장 특이적 나트륨-칼륨-염소 공동수송체 연구에 적합.
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제품명
S12A1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human S12A1 (AA range: 595–645) |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 6557 |
| Human Swiss-Prot No. | Q13621 |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle’s loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to diuretics such as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
[provided by RefSeq, May 2010]
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