ELK Biotechnology SEK1/MKK4 (phospho-Ser257/Thr261) rabbit pAb
세린257/트레오닌261 인산화 SEK1/MKK4 단백질을 인식하는 토끼 폴리클로날 항체로, WB·ELISA·IHC에 사용 가능. 세포 내 MAPK 신호전달 연구에 적합하며, 사람·생쥐·랫트 반응성. 고순도 IgG, -20°C에서 1년 보관.
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SEK1/MKK4 (phospho-Ser257/Thr261) Rabbit Polyclonal Antibody
제품 개요
이 항체는 인간 SEK1/MKK4 단백질의 Ser257 및 Thr261 인산화 부위를 인식하는 토끼 폴리클로날 항체입니다. MAPK 신호전달 경로 연구 및 세포 내 인산화 조절 기전 분석에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | SEK1/MKK4 (phospho-Ser257/Thr261) rabbit pAb |
| Alternative Names | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4), MAPKK 4, JNK-activating kinase 1, MAPK/ERK kinase 4, MEK 4, SAPK/ERK kinase 1, SEK1, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, c-Jun N-terminal kinase kinase 1, JNKK |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB: 1:500–2000; IHC-p: 1:50–300; ELISA: 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human SEK1 (Ser257 and Thr261) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kDa |
| Gene ID (Human) | 6416 |
| Human Swiss-Prot No. | P45985 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as integration points for multiple biochemical signals and are involved in diverse cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. In mouse, a similar protein has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. (RefSeq, Jul 2013)
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