ELK Biotechnology SEK1/MKK4 (phospho-Thr261) rabbit pAb
SEK1/MKK4 (phospho-Thr261) rabbit polyclonal antibody로, MAPK 신호전달 연구에 적합합니다. WB, ELISA, IHC에 사용 가능하며, 인간, 마우스, 랫트 시료에 반응합니다. 세포 내 위치는 세포질과 핵이며, -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
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제품명
SEK1/MKK4 (phospho-Thr261) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human SEK1 (Thr261) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kDa |
| Gene ID (Human) | 6416 |
| Human Swiss-Prot No. | P45985 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. (RefSeq, Jul 2013)
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