ELK Biotechnology SGK3 (phospho-Thr320) rabbit pAb
SGK3 (phospho-Thr320) rabbit pAb는 인산화된 SGK3 단백질을 특이적으로 인식하는 폴리클로날 항체입니다. WB 및 IHC 분석에 적합하며, 세포 내 소포 및 초기 엔도솜에서의 SGK3 활성 연구에 활용됩니다. -20°C에서 1년간 안정 보관 가능합니다.
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SGK3 (phospho-Thr320) Rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SGK3 (phospho-Thr320) rabbit pAb |
| Alternative Names | Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1); Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized phospho peptide around human SGK3 (Thr320) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 54 kD |
| GeneID (Human) | 100533105 |
| Human Swiss-Prot No. | Q96BR1 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasmic vesicle, early endosome, and recycling endosome. Endosomal localization is essential for complete kinase activity and colocalization with the kinase responsible for phosphorylating Ser-486, enabling PDPK1 phosphorylation of Thr-320 for full SGK3 activation. Localized in vesicle-like structures and early endosomes, and colocalizes with SLC9A3/NHE3 in recycling endosomes.
배경 (Background)
This gene belongs to the Ser/Thr protein kinase family and encodes a phosphoprotein containing a PX (phox homology) domain. The protein phosphorylates multiple target proteins and plays a role in neutral amino acid transport and activation of potassium and chloride channels. Alternative splice variants encoding different isoforms have been characterized. [Provided by RefSeq, Jul 2008]
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