ELK Biotechnology SirT1 (phospho-Ser27) rabbit pAb
SirT1 (phospho-Ser27) rabbit polyclonal antibody for detection of phosphorylated SIRT1 in human, rat, and mouse samples. Suitable for WB, ELISA, and IHC applications. High specificity to Ser27 phosphorylation site with stable storage at -20°C.
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SirT1 (phospho-Ser27) Rabbit pAb
제품 개요
SirT1 (phospho-Ser27) rabbit polyclonal antibody는 인간 SirT1 단백질의 Ser27 인산화 부위를 인식하도록 설계된 항체입니다. NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) 단백질 검출에 사용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SirT1 (phospho-Ser27) rabbit pAb |
| Alternative Names | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 3.5.1.-), Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2 Cleaved into: SirtT1 75 kDa fragment (75SirT1) |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human SirT1 (Ser27) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85–110 kDa |
| GeneID (Human) | 23411 |
| Human Swiss-Prot No | Q96EB6 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
- Nucleus, PML body, Cytoplasm
- Recruited to nuclear bodies via interaction with PML (PubMed:12006491)
- Colocalized with APEX1 in nucleus (PubMed:19934257)
- Found in nucleolus, euchromatin, heterochromatin, and inner membrane (PubMed:15469825)
- Shuttles between nucleus and cytoplasm (By similarity)
- Colocalizes in nucleus with XBP1 isoform 2 (PubMed:20955178)
- SirtT1 75 kDa fragment: Cytoplasm, Mitochondrion
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. Human sirtuins are suggested to function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene belongs to class I of the sirtuin family. Alternative splicing results in multiple transcript variants. (RefSeq, Dec 2008)
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