ELK Biotechnology Skp2 (phospho-Ser64) rabbit pAb

제품명

Skp2 (phospho-Ser64) rabbit pAb

공급업체

ELK Biotechnology

제품 설명

Skp2 (phospho-Ser64) rabbit polyclonal antibody는 인산화된 Skp2 단백질을 특이적으로 인식하며, 세포 내 사이클 조절 및 단백질 유비퀴틴화 연구에 유용합니다. 다양한 응용 분야(WB, ELISA, IHC)에 적합하며, 사람, 생쥐, 랫트 시료에서 반응성을 보입니다.

제품 스펙

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase.