ELK Biotechnology Smad2 (phospho-Ser465/467) rabbit pAb
Smad2 단백질의 Ser465/467 인산화 상태를 검출하는 토끼 폴리클로날 항체. WB, ELISA, IHC에 사용 가능하며, TGF-β 신호전달 연구에 적합. 고순도 IgG로 -20°C에서 1년 보관 가능.
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제품명
Smad2 (phospho-Ser465/467) rabbit pAb
대체 명칭
Mothers against decapentaplegic homolog 2 (MAD homolog 2), Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB, ELISA, IHC |
| Recommended Dilutions | WB: 1:500–2000 IHC-p: 1:50–300 ELISA: 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human Smad2 (Ser465 and Ser467) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 58 kD |
| Gene ID (Human) | 4087 |
| Human Swiss-Prot No. | Q15796 |
| Species Reactivity | Human, Mouse, Rat |
세포 내 위치
Cytoplasm, Nucleus.
Cytoplasmic and nuclear in the absence of TGF-beta. Upon TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499).
On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081).
Localized mainly to the nucleus in early embryo development, expression becomes evident in the cytoplasm at blastocyst and epiblast stages (By similarity).
배경 정보
The protein encoded by this gene belongs to the SMAD family, which is similar to the gene products of Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma.
SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.
This protein mediates the TGF-β signal and regulates cellular processes such as proliferation, apoptosis, and differentiation.
It is recruited to the TGF-β receptors through interaction with the SMAD anchor for receptor activation (SARA) protein.
Upon TGF-β stimulation, it becomes phosphorylated, dissociates from SARA, and associates with SMAD4, which is essential for nuclear translocation.
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