ELK Biotechnology SMC1 (phospho-Ser360) rabbit pAb
SMC1 (phospho-Ser360) rabbit polyclonal antibody로, 인간, 마우스, 랫트 시료에 반응합니다. WB, ELISA, IHC에 사용 가능하며, 세포 내 염색체 및 핵에서 발현되는 SMC1A 단백질의 인산화 상태 분석에 적합합니다. -20°C에서 1년 보관 가능합니다.
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제품명
SMC1 (phospho-Ser360) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human SMC1 (Ser360) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 143 kDa |
| Gene ID (Human) | 8243 |
| Human Swiss-Prot No. | Q14683 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Nucleus; Chromosome; Chromosome centromere, kinetochore. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most cohesin complexes dissociate from chromatin, probably due to phosphorylation by PLK, except at centromeres where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to dissociation and chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting phosphorylation does not regulate cohesin function. |
Background
Structural maintenance of chromosomes 1A (SMC1A) is essential for proper cohesion of sister chromatids, ensuring correct segregation during cell division. The cohesin complex, containing SMC3 and either SMC1B or SMC1A, mediates this cohesion. Most cohesin complexes dissociate before mitosis except those at kinetochores. SMC1A interacts with BRCA1 and is phosphorylated by ATM, suggesting a role in DNA repair. The SMC1A gene, located on the X chromosome, escapes X inactivation, and mutations are associated with Cornelia de Lange syndrome.
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