Thermo Fisher Scientific IL4R Monoclonal Antibody (3E5)
인간 IL4R 단백질을 표적으로 하는 마우스 단클론 항체로 ELISA에 적합합니다. 비결합형 액상 형태이며, -20°C에서 보관합니다. 알레르기 염증 관련 연구 및 IL4/IL13 신호전달 분석에 활용됩니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E5 |
| Immunogen | IL4R (NP_000409, 26 a.a. approximately 135 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MKVLQEPTCV SDYMSISTCE WKMNGPTNCS TELRLLYQLV FLLSEAHTCI PENNGGAGCV CHLLMDDVVS ADNYTLDLWA GQQLLWKGSF KPSEHVKPRA PGNLTVHTNV
Target Information
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammation.
The IL4 response promotes Th2 differentiation. The secreted extracellular domain of IL4R alpha (sIL4R alpha) can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells, but has no signaling ability.
Allelic variations in the IL4RA gene have been associated with atopy, which may manifest as allergic rhinitis, sinusitis, asthma, or eczema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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